Michael C Holmes Selected Research

Zinc Finger Nucleases

3/2017	Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34+ Hematopoietic Stem and Progenitor Cells.
8/2015	Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.
1/2014	Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection.
11/2013	Robust ZFN-mediated genome editing in adult hemophilic mice.
3/2013	Use of zinc-finger nucleases to knock out the WAS gene in K562 cells: a human cellular model for Wiskott-Aldrich syndrome.
5/2012	Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer.
6/2005	Highly efficient endogenous human gene correction using designed zinc-finger nucleases.

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Michael C Holmes Research Topics

Disease

5	Neoplasms (Cancer) 01/2022 - 05/2012
5	Infections 10/2017 - 07/2008
3	HIV Infections (HIV Infection) 10/2017 - 03/2013
2	Cerebrovascular Disorders (Cerebrovascular Occlusion) 11/2021 - 09/2020
2	Fabry Disease (Fabry's Disease) 11/2021 - 09/2020
2	Latent Infection 01/2019 - 01/2018
2	Sickle Cell Anemia (Hemoglobin S Disease) 03/2017 - 04/2015
2	Wiskott-Aldrich Syndrome 01/2016 - 03/2013
1	Glioblastoma (Glioblastoma Multiforme) 01/2022
1	Necrosis 01/2022
1	Mucopolysaccharidosis I (Hurler Syndrome) 01/2019
1	Metabolic Diseases (Metabolic Disease) 01/2019
1	beta-Thalassemia (Cooley's Anemia) 09/2018
1	Mucopolysaccharidosis II (Hunter Syndrome) 01/2018
1	Vesicular Stomatitis 11/2017
1	Primary Immunodeficiency Diseases 01/2016
1	Melanoma (Melanoma, Malignant) 08/2015
1	Cystic Fibrosis (Mucoviscidosis) 04/2015
1	Hypersensitivity (Allergy) 01/2015
1	X-Linked Combined Immunodeficiency Diseases (X Linked Severe Combined Immunodeficiency) 06/2014
1	Hemophilia B (Haemophilia B) 11/2013
1	Ewing Sarcoma (Sarcoma, Ewing) 07/2013
1	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 07/2013
1	Acquired Immunodeficiency Syndrome (AIDS) 06/2013
1	Chromosome Breakage 03/2013
1	Muscular Diseases (Myopathy) 01/2013
1	Wilms Tumor (Wilm's Tumor) 05/2012
1	Leukemia 05/2012
1	Genetic Translocation (Chromosomal Translocation) 06/2011
1	Genomic Instability 06/2011
1	Inborn Genetic Diseases (Disease, Hereditary) 02/2007
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 06/2005

Drug/Important Bio-Agent (IBA)

7	Zinc Finger NucleasesIBA 03/2017 - 06/2005
4	AntigensIBA 10/2017 - 05/2012
3	EnzymesIBA 11/2021 - 01/2019
3	Transcription Activator-Like Effector NucleasesIBA 01/2019 - 07/2013
3	GlobinsIBA 09/2018 - 01/2015
2	Chimeric Antigen ReceptorsIBA 01/2022 - 06/2012
2	globotriaosylceramide (globotriosylceramide)IBA 11/2021 - 09/2020
2	HydrolasesIBA 09/2020 - 01/2019
2	GlycosaminoglycansIBA 01/2019 - 01/2018
2	Glycoproteins (Glycoprotein)IBA 11/2017 - 04/2015
2	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2017 - 05/2012
2	Proteins (Proteins, Gene)FDA Link 01/2016 - 03/2013
2	Chemokine ReceptorsIBA 01/2016 - 03/2013
1	SteroidsIBA 01/2022
1	aldesleukin (Proleukin)FDA Link 01/2022
1	GalactosidasesIBA 11/2021
1	alpha-Galactosidase (Beano)IBA 09/2020
1	AlbuminsIBA 01/2019
1	Iduronidase (alpha-L-Iduronidase)IBA 01/2019
1	Fetal Hemoglobin (Hemoglobin F)IBA 09/2018
1	Iduronic Acid (Iduronate)IBA 01/2018
1	Complement System Proteins (Complement)IBA 11/2017
1	Peptides (Polypeptides)IBA 11/2016
1	Antiviral Agents (Antivirals)IBA 01/2016
1	Codon (Codons)IBA 04/2015
1	Chloride Channels (Chloride Channel)IBA 04/2015
1	Deoxyribonucleases (DNase)FDA Link 01/2015
1	Complementary DNA (cDNA)IBA 06/2014
1	Pharmaceutical PreparationsIBA 01/2014
1	Factor IX (Coagulation Factor IX)FDA LinkGeneric 11/2013
1	Pyridinolcarbamate (P23)IBA 07/2013
1	CC ChemokinesIBA 03/2013
1	DNA (Deoxyribonucleic Acid)IBA 03/2013
1	Monoclonal AntibodiesIBA 06/2012
1	DNA Ligase ATPIBA 06/2011
1	DNA Ligases (Ligases, DNA)IBA 06/2011
1	CCR5 Receptors (CCR5 Receptor)IBA 07/2008

Therapy/Procedure

5	Therapeutics 11/2021 - 02/2007
2	Highly Active Antiretroviral Therapy (HAART) 01/2018 - 03/2014
2	Cell- and Tissue-Based Therapy (Cell Therapy) 03/2017 - 01/2013
2	Immunotherapy 01/2017 - 05/2012
1	Enzyme Replacement Therapy 09/2020
1	Stem Cell Transplantation 01/2016
1	Transplantation 01/2013
1	Investigational Therapies (Experimental Therapy) 06/2012